LifesMiracle's ingredients are among the most widely researched in the nutrition industry. Below are links to the most recent published independent university studies on the ingredients to validate safety and efficacy. LifesMiracle products do not contain any ingredients found on the World Anti-Doping Agency's athlete banned substance list. Click here to see the banned supplement list on the WADA website.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Açaí (Euterpe oleracea mart.)

Açaí is a small berry that grows wild in the tropical areas of South America. It contains many antioxidants which are thought to protect body cells from the damaging effects of chemical reactions with oxygen (oxidation). According to some research, Açaí has more antioxidant content than cranberry, raspberry, blackberry, strawberry, or blueberry. The benefits of consuming the fruit can include cholesterol reduction, anti-inflammatory effects, antioxidant benefits and many others.

Açaí Berries Health Benefits WebMD examines the health benefits of the Açaí berries, known as a “superfood” because of their many health benefits, anti-aging properties, and weight loss claims. WebMD Medical Reference.

Study at the University of Florida on the effect of Açaí on cancer cells from the University of Florida Website.

Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Açaí) extracts in mesenteric vascular bed Rocha AP, Carvalho LC, Sousa MA, Madeira SV, Sousa PJ, Tano T, Schini-Kerth VB, Resende AC, Soares de Moura R. Vascul Pharmacol.2007 Feb;46(2):97-104. Epub 2006 Sep 1

Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleraceae mart. (Açaí) Schauss AG, Wu X, Prior RL, Ou B, Huang D, Owens J, Agarwal A, Jensen GS, Hart AN, Shanbrom E. J Agric Food Chem. 2006 Nov 1;54(22):8604-10

Total oxidant scavenging capacities of Euterpe oleracea Mart. (Açaí) fruits. Lichtenthäler R, Rodrigues RB, Maia JG, Papagiannopoulos M, Fabricius H, Marx F. Int J Food Sci Nutr. 2005 Feb;56(1):53-64

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Acidophilus (See Lactobacillus Acidophilus)

Apple Pectin

Apple pectin's beneficial effect on the digestive tract stems from its ability to support and maintain intestinal balance. It may also help to support healthy cholesterol levels by binding with cholesterol and fats to be eliminated through the digestive tract before they can be absorbed, which may help to reduce the risk of cardio-vascular problems. It is also believed to slow the absorption of dietary sugars, which may be helpful in supporting healthy blood sugar levels. Another area of research focuses on the anti-aging, especially in the skin, benefits of a compound called Oligogalacturonides (OGA).

Apple pectin may protect against metabolic syndrome A highly methoxylated apple pectin (HMAP) may counter changes in metabolism and cardiovascular health associated with the metabolic syndrome, according to a study from Spain.

Hypocholesterolaemic effects of apple Pectin in moderately hypercholesterolaemic individuals. Sirtori CR, Triolo M, Bosisio R, Bondioli A, Calabresi L, De Vergori V, Gomaraschi M, Mombelli G, Pazzucconi F, Zacherl C, Arnoldi A. Br J Nutr. 2011 Oct 28:1-8. [Epub ahead of print] PMID: 22032303 [PubMed - as supplied by publisher]

Oligogalacturonides (OGA) improve tissue organization of in vitro reconstructed skin Lebreton-Decoster C, Rousselle P, Laperdrix C, Lubrano C, Robin JR, Coulomb B. Int J Cosmet Sci. 2011 Oct;33(5):455-61. doi: 10.1111/j.1468-2494.2011.00655.x. Epub 2011 Apr 21 PMID: 21507016 [PubMed - in process]

An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-κB pathway in a mouse model of colitis-associated colon cancer. Liu L, Li YH, Niu YB, Sun Y, Guo ZJ, Li Q, Li C, Feng J, Cao SS, Mei QB. Carcinogenesis. 2010 Oct;31(10):1822-32. Epub 2010 Apr 16. PMID: 20400476 [PubMed - indexed for MEDLINE]

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Artichoke

Artichoke Extract has been in use by herbalists for over a hundred years as a digestive tonic. Recent scientific studies have confirmed that Artichoke Extract may promote healthy digestive function through its ability to aid in fat digestion. It also contains antioxidant flavonoids, such as apigenin and luteolin, that have been shown to support the cardio-vascular system.

The beneficial health side effects of artichoke leaf extract are due to the promotion of bile flow in the body. This increased bile flow especially promotes increased digestion of fat and serves to move toxins from the liver on to the intestine for elimination. Artichoke is also high in FOS, which has a large number of benefits.

Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231. Mileo AM, Di Venere D, Linsalata V, Fraioli R, Miccadei S. J Cell Physiol. 2011 Dec 14. doi: 10.1002/jcp.24029. [Epub ahead of print] PMID: 22170094 [PubMed - as supplied by publisher]

Dietary fructooligosaccharides (FOS) from artichokes and other foods potential benefits on health. Sabater-Molina M, Larqué E, Torrella F, Zamora S. J Physiol Biochem. 2009 Sep;65(3):315-28. Review. PMID: 20119826 [PubMed - indexed for MEDLINE]

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Ashwagandha

Ashwagandha (withania somnifera)

Ashwagandha has been used in India for centuries to enhance the body's resistive functions during high-stress situations.

The key to its effectiveness lies in constituents known as withanolides, which help normalize a wide range of biochemical functions, including the promotion of apoptosis to mutated cells and the protection from the degradation of collagen.

In addition, Ashwagandha is also used to enhance sexual potency for both men and women. Ashwagandha is one of the most researched herbs and may help with the following:

  • Immune system protection
  • Combats the effects of stress
  • Improves learning, memory, and reaction time
  • Reduces anxiety and depression without causing drowsiness
  • Supports normal blood sugar levels
  • Lowers cholesterol
  • Reduces brain-cell degeneration
  • Contains anti-malarial properties
  • Offers anti-inflammatory benefits

Therapeutic effect of Withania somnifera on pristane-induced model of SLE (Lupus). Minhas U, Minz R, Das P, Bhatnagar A. Inflammopharmacology. 2011 Dec 13. [Epub ahead of print] PMID: 22160928 [PubMed - as supplied by publisher]

Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. Munagala R, Kausar H, Munjal C, Gupta RC. Carcinogenesis. 2011 Nov;32(11):1697-705. Epub 2011 Aug 22. PMID: 21859835 [PubMed - in process]

Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2. Mayola E, Gallerne C, Esposti DD, Martel C, Pervaiz S, Larue L, Debuire B, Lemoine A, Brenner C, Lemaire C. Apoptosis. 2011 Oct;16(10):1014-27. PMID: 21710254 [PubMed - in process]

Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. Malviya N, Jain S, Gupta VB, Vyas S.Acta Pol Pharm. 2011 Jan-Feb;68(1):3-8. Review. PMID: 21485695 [PubMed - indexed for MEDLINE]

Protective effect of Withania somnifera and Cardiospermum halicacabum extracts against collagenolytic degradation of collagen. Ganesan K, Sehgal PK, Mandal AB, Sayeed S. Appl Biochem Biotechnol. 2011 Oct;165(3-4):1075-91. Epub 2011 Jul 26. PMID: 21789568 [PubMed - in process]

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Bifidus (Bifidobacterium longum)

With the help of Bifidobacteria and other similar micro-organisms, our bodies can metabolize sugars and regulate the acid/alkaline balance of the GI tract. By encouraging these helpful microflora to colonize the GI tract, a mechanism for boosting digestive functionality with significant impacts on health has been confirmed by many scientific studies. Bifidus is one of the most important for keeping the digestive system in balance.

The role of intestinal bifidobacteria on immune system development in laboratory animals. Dong P, Yang Y, Wang WP. Early Hum Dev. 2010 Jan 25. [Epub ahead of print] PMID: 20106610 [PubMed - as supplied by publisher]

A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients. Gianotti L, Morelli L, Galbiati F, Rocchetti S, Coppola S, Beneduce A, Gilardini C, Zonenschain D, Nespoli A, Braga M. World J Gastroenterol. 2010 Jan 14;16(2):167-75. PMID: 20066735 [PubMed - in process]

Bifidobacterium as an oral delivery carrier of oxyntomodulin for obesity therapy: inhibitory effects on food intake and body weight. Long RT, Zeng WS, Chen LY, Guo J, Lin YZ, Huang QS, Luo SQ. Int J Obes (Lond). 2010 Jan 12. [Epub ahead of print] PMID: 20065960 [PubMed - as supplied by publisher]

Impact of a symbiotic food on the gut microbial ecology and metabolic profiles. Vitali B, Ndagijimana M, Cruciani F, Carnevali P, Candela M, Guerzoni ME, Brigidi P. BMC Microbiol. 2010 Jan 7;10:4. PMID: 20055983 [PubMed - indexed for MEDLINE]

Bifidobacteria inhibit the inflammatory response induced by gliadins (celiac disease) in intestinal epithelial cells via modifications of toxic peptide generation during digestion. Laparra JM, Sanz Y. J Cell Biochem. 2010 Jan 5. [Epub ahead of print] PMID: 20052669 [PubMed - as supplied by publisher]

Pivotal Advance: Bifidobacteria and gram-negative bacteria differentially influence immune responses in the pro inflammatory milieu of celiac disease. De Palms G, Ci-nova J, Stepparent R, Tuck ova L, Sanz Y. J Leukocyte Biol. [Epub ahead of print] PMID: 20007908 [PubMed - as supplied by publisher]

Prevention of Escherichia coli O157:H7 infection in gnotobiotic mice associated with Bifidobacterium strains. Yoshimura K, Matsui T, Itoh K. Antonie Van Leeuwenhoek. 2010 Feb;97(2):107-17. Epub 2009 Nov 13. PMID: 19911297 [PubMed - in process]

Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice. Lee IA, Bae EA, Lee JH, Lee H, Ahn YT, Huh CS, Kim DH. Inflamm Res. 2009 Nov 1. [Epub ahead of print] PMID: 19882302 [PubMed - as supplied by publisher]

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Blueberry (See Pterostilbene)

BMI

Body Mass Index (BMI)

The BMI is a measure of your weight relative to your height. Combining this with information about your additional risk factors yields your risk for developing obesity-associated diseases and early death. Click here to check your BMI.

The Evaluation of Body Composition: A Useful Tool for Clinical Practice. Thibault R, Pichard C. Ann Nutr Metab. 2011 Dec 16;60(1):6-16. [Epub ahead of print] PMID: 22179189 [PubMed - as supplied by publisher]

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Buchu

Buchu

Buchu is a small shrub native to South Africa where it is often used both as a flavoring agent and as a medicine. It has antiseptic and diuretic properties, and acts as a kidney tonic.

Buchu herb is used to treat blood in the urine, bladder infections and other chronic urinary tract disorders. It is also said to be an effective remedy for kidney stones, prostate disorders, cystitis, and rheumatism.

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Cacao

Cacao has been used for thousands of years as a healing agent. More importantly, modern science claims that it's good for supporting the health of your heart and arteries, good for your skin, has nearly twice the antioxidants of red wine and up to three times those found in Green Tea. Taken as a dietary supplement in capsule form, you can add all its health benefits without the added fat and calories.



Cocoa phytochemicals: recent advances in molecular mechanisms on health. Kim J, Kim J, Shim J, Lee CY, Lee KW, Lee HJ. Crit Rev Food Sci Nutr. 2014;54(11):1458-72. doi: 10.1080/10408398.2011.641041. Review. PMID: 24580540 [PubMed - indexed for MEDLINE]



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Caralluma Fimbriata

Caralluma Fimbriata is a cactus found in India and it's been used for centuries. It contains pregnane glycosides which blocks fat formation through citrate lyase. It also suppresses appetite by signaling the hypothalamus in the brain that we're just not hungry and at the same time increasing your energy level so you burn off more fat.

Safety assessment of a hydroethanolic extract of Caralluma fimbriata Odendaal AY, Deshmukh NS, Marx TK, Schauss AG, Endres JR, Clewell AE. Int J Toxicol. 2013 Sep-Oct;32(5):385-94. doi: 10.1177/1091581813492827. Epub 2013 Jun 14. PMID: 23771637 [PubMed - indexed for MEDLINE]

Recent update in management of obesity and Overweight Patients: Standardized extract of Caralluma Fimbriata safe and effective Therapy Bansi Saboo, Dia care, Ahmedabad, India Hemant Zaveri, Medical Advisor Zydus Nutriva Ahmedabad, India International Journal of Clinical Cases and Investigations 2011. Volume 2 (Issue 2), 5:9, 6th February 2011

Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women.Kuriyan R, Raj T, Srinivas SK, Vaz M, Rajendran R, Kurpad AV. Appetite. 2007 May;48(3):338-44. Epub 2006 Nov 13.PMID:17097761[PubMed - indexed for MEDLINE]

Pharmacological Review of Caralluma R.Br. with Special Reference to Appetite Suppression and Anti-Obesity.Dutt HC, Singh S, Avula B, Khan IA, Bedi YS. J Med Food. 2011 Dec 22. [Epub ahead of print] PMID: 22191633 [PubMed - as supplied by publisher]

Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract.Kamalakkannan S, Rajendran R, Venkatesh RV, Clayton P, Akbarsha MA. J Nutr Metab. 2010;2010:285301. Epub 2010 Dec 28. PMID: 21234320 [PubMed]

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Chá de Bugre (Cordia salicifolia)

Chá de Bugre is the Brazilian secret to weight loss because of its ability to stimulate fat burning and to gently energize your metabolism while at the same time lowering your cravings for food. There are also studies showing how Chá de Bugre can reduce fatty deposits and reduce the amount and appearance of cellulite.

Phytochemical investigation on leaf extract of Cordia salicifolia as an inhibitor of growth of Helicobacter pylori. Menghini L, Epifano F, Leporini L, Pagiotti R, Tirillini B. J Med Food. 2008 Mar;11(1):193-4. PMID: 18361757 [PubMed - indexed for MEDLINE]

Cha de bugre Health Benefits WebMD examines the health benefits of Cha de bugre, renown as a Brazilian weight loss herb and as a herb to reduce cellulite, as well as its many other health benefits, anti-aging properties, and weight loss claims. WebMD Medical Reference

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ChromeMate

ChromeMate

ChromeMate® is a niacin-bound chromium called chromium polynicotinate.

ChromeMate brand chromium polynicotinate may help increase the effectiveness of chromium, an essential trace mineral that may help support blood sugar levels already within normal range.* ChromeMate was introduced to the U.S. market in 1987 and has been extensively studied for its efficacy and safety in supporting blood sugar levels already within normal range, and healthy cholesterol levels already within normal range and a healthy body weight. ChromeMate has been determined GRAS by a leading independent group of toxicologists.

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Colloidal Clay Mask

Colloidal Clay

A colloidal clay refers to one that contains particles fine enough to penetrate deep into the inner layer of the skin. There are few true colloidal clays the world and this is why Canadian clay is superior to many others used for skin care.

Due to the large surface area of the particles and the fact that they are ionic, colloidal clay is much more reactive than others.

Canadian Glacial Clay has been proven to be one ingredient that addresses issues such as removal of toxins, improvement in circulation, healing of skin conditions such as acne and reduction of muscle pain and inflammation.

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Coral Calcium Ionic Minerals

Coral

Activated, Biologically Balanced Ionic Coral may be one of the most exciting discoveries ever in natural health. It contains more than 70 minerals that naturally occur with a chemical makeup almost identical to human bone and has been used surgically for bone reconstruction. Perhaps its most important atribute is to help bring the pH levels of the body back into balance, while providing the minerals that the body needs in a form that it can use.

Effects of calcium sources and soluble silicate on bone metabolism and the related gene expression in mice. Maehira F, Miyagi I, Eguchi Y. Nutrition. 2009 May;25(5):581-9. Epub 2009 Jan 3. PMID: 19121918 [PubMed - indexed for MEDLINE]

The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs. Ripamonti U, Crooks J, Khoali L, Roden L. Biomaterials. 2009 Mar;30(7):1428-39. Epub 2008 Dec 9. PMID: 19081131 [PubMed - indexed for MEDLINE]

The use of Coral in bone reconstrution. Olah L, Borbas L. Acta Bioeng Biomech. 2008;10(1):61-6. PMID: 18634355 [PubMed - indexed for MEDLINE]

Calcium absorption from the ingestion of coral-derived calcium by humans. Ishitani K, Itakura E, Goto S, Esashi T. J Nutr Sci Vitaminol (Tokyo). 1999 Oct;45(5):509-17. PMID: 10683804 [PubMed - indexed for MEDLINE]

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DGL (Deglycyrrhizinated Licorice)

Deglycyrrhizinated licorice, or commonly referred to by the acronym
DGL
, is an herbal supplement typically used in the treatment of gastric
and duodenal ulcers. It is made from licorice from which the glycyrrhizin has
been removed.

Licorice has many outstanding characteristics but when the glycyrrhizin is
left intact, it may cause some unwanted side effects, such as water retension (edema) or may cause hypertension. DGL gives you all the benefits without
any of the side effects.

  • Muscle cramps Preliminary clinical research suggests taking licorice might reduce muscle cramps in people with liver disease (hepatic cirrhosis) or in people undergoing treatment for kidney failure (hemodialysis);
  • Stomach ulcers There is some evidence that deglycyrrhzinated licorice will speed the healing of stomach ulcers;
  • Weight loss Licorice seems to reduce body fat. The deglycyrrhzinated form does not cause water retention the way that un-deglycyrrhzinated will;
  • Arthritis;
  • Lupus;
  • Infections;
  • Chronic fatigue syndrome (CFS).

Deglycyrrhizinated liquorice in aphthous ulcers. Das SK, Das V, Gulati AK, Singh VP.J Assoc Physicians India. 1989 Oct;37(10):647. PMID: 2632514 [PubMed - indexed for MEDLINE]

Studies on the protective effect of deglycyrrhinised liquorice against aspirin (ASA) and ASA plus bile acid-induced gastric mucosal damage, and ASA absorption in laboratory animals Russell RI, Morgan RJ, Nelson LM. Scand J Gastroenterol Suppl. 1984;92:97-100. PMID: 6588541 [PubMed - indexed for MEDLINE]

Deglycyrrhizinised liquorice (DGL) and the renewal of rat stomach epithelium. van Marle J, Aarsen PN, Lind A, van Weeren-Kramer J. Eur J Pharmacol. 1981 Jun 19;72(2-3):219-25. PMID: 7250207 [PubMed - indexed for MEDLINE]

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EGCG (See also GreenTea)

Green tea is said to provide excellent health benefits when consumed in moderation on a regular basis. Green tea is an excellent source of epigallocatechin gallate, also known as Epigallocatechin Gallate (EGCG), which is an antioxidant believed to have positive effects in protecting the human body against various types of degenerative health problems. Research has shown you can improve your overall health by incorporating it as a regular part of your daily diet.

Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2. Britschgi A, Simon HU, Tobler A, Fey MF, Tschan MP. Br J Haematol. 2010 Jan 20. [Epub ahead of print] PMID: 20096012 [PubMed - as supplied by publisher]

Effects of oral consumption of the green tea polyphenol EGCG in a murine model for human Sjogren’s syndrome, an autoimmune disease Kevin Gillespie, DMD,* Isamu Kodani, MD, PhD,* Douglas P. Dickinson, PhD, Kalu U.E. Ogbureke, MD, PhD, Amy M. Camba, BS, Mengjie Wu, DMD, PhD, Stephen Looney, PhD, Tin-Chun Chu, Haiyan Qin, MS, Frederick Bisch, DMD, Mohamed Sharawy, PhD, George S. Schuster, DDS, PhD, and Stephen D. De Hsu, PhD

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Ellagic Acid

Ellagic Acid is a polyphenol that is produced by nature in a variety of fruits, with the most concentrated coming from Red Raspberries. Research has shown you can improve your overall health by incorporating it as a regular part of your daily diet.

Effects of Ellagic Acid in human Neuroblastoma Cells Christina Alfredsson Faculty of Health, Science and Technology Biomedical Sciences DISSERTATION Karlstad University Studies 2013:48

Ellagic acid improves hyperalgesia and cognitive deficiency in 6-hydroxidopamine induced rat model of Parkinson's disease. Dolatshahi M, Farbood Y, Sarkaki A, Mansouri SM, Khodadadi A.

Influence of ellagic acid on prostate cancer cell proliferation: a caspase-dependent pathway. Malik A, Afaq S, Shahid M, Akhtar K, Assiri A. Asian Pac J Trop Med. 2011 Jul;4(7):550-5. doi: 10.1016/S1995-7645(11)60144-2. PMID 21803307

Research progress on the anticarcinogenic actions and mechanisms of ellagic acid Hong-Mei Zhang, Lei Zhao, Hao Li, Hao Xu, Wen-Wen Chen, and Lin Tao Cancer Biol Med. 2014 Jun; 11(2): 92–100.doi:  10.7497/j.issn.2095-3941.2014.02.004 PMCID: PMC4069806

Identification of Ellagic Acid analogues as potent inhibitor of protein Kinase CK2:A chemopreventive role in oral cancer. Srivastava R, Akthar S, Sharma R, Mishra S. 2015 Jan 30;11(1):21-6. doi: 10.6026/97320630011021. eCollection 2015.PMID: 25780276

Ellagic Acid induces cell cycle arrest and apoptosis through TGF-β/Smad3 signaling pathway in human breast cancer MCF-7 cells Chen HS, Bai MH, Zhang T, Li GD, Liu M. Int J Oncol. 2015 Apr;46(4):1730-8. doi: 10.3892/ijo.2015.2870. Epub 2015 Feb 3. PMID: 25647396

Ellagic Acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells.Umesalma S, Nagendraprabhu P, Sudhandiran G. Mol Cell Biochem. 2015 Jan;399(1-2):303-13. doi: 10.1007/s11010-014-2257-2. Epub 2014 Oct 30. PMID: 25355159

Effects of Ellagic Acid on angiogenic factors in prostate cancer cells. Vanella L, Di Giacomo C, Acquaviva R, Barbagallo I, Li Volti G, Cardile V, Abraham NG, Sorrenti V. Cancers (Basel). 2013 Jun 19;5(2):726-38. PMID:24216999

Apoptotic markers in a prostate cancer cell line: effect of Ellagic Acid.Vanella L, Di Giacomo C, Acquaviva R, Barbagallo I, Cardile V, Kim DH, Abraham NG, Sorrenti V. Oncol Rep. 2013 Dec;30(6):2804-10. doi: 10.3892/or.2013.2757. Epub 2013 Sep 30. PMID: 24085108

The inhibitory effect of Ellagic Acid on cell growth of ovarian carcinoma cells.Chung YC, Lu LC, Tsai MH, Chen YJ, Chen YY, Yao SP, Hsu CP. Evid Based Complement Alternat Med. 2013;2013:306705. doi: 10.1155/2013/306705. Epub 2013 Jun 16. PMID: 23843871

In vitro antioxidant and antiproliferative effects of Ellagic Acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Qiu Z, Zhou B, Jin L, Yu H, Liu L, Liu Y, Qin C, Xie S, Zhu F. Food Chem Toxicol. 2013 Sep;59:428-37. doi: 10.1016/j.fct.2013.06.025. Epub 2013 Jun 26. PMID: 23811531

Ellagic Acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways.Ho CC, Huang AC, Yu CS, Lien JC, Wu SH, Huang YP, Huang HY, Kuo JH, Liao WY, Yang JS, Chen PY, Chung JG. Environ Toxicol. 2014 Nov;29(11):1262-74. doi: 10.1002/tox.21857. Epub 2013 Mar 30. PMID: 23554011

Ellagic Acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury. Farbood Y, Sarkaki A, Dianat M, Khodadadi A, Haddad MK, Mashhadizadeh S. Life Sci. 2015 Mar 1;124:120-7. doi: 10.1016/j.lfs.2015.01.013. Epub 2015 Jan 28. PMID: 25637685

Inhibition of allergic airway inflammation through the blockage of NF-κB activation by Ellagic Acid in an ovalbumin-induced mouse asthma model. Zhou E, Fu Y, Wei Z, Yang Z. Food Funct. 2014 Sep;5(9):2106-12. doi: 10.1039/c4fo00384e. PMID: 24998475

Ellagic acid, an NF-κB inhibitor, ameliorates renal function in experimental diabetic nephropathy. Ahad A, Ganai AA, Mujeeb M, Siddiqui WA. Chem Biol Interact. 2014 Aug 5;219:64-75. doi: 10.1016/j.cbi.2014.05.011. Epub 2014 May 28. PMID: 24877639

The effects of proresolution of Ellagic Acid in an experimental model of allergic airway inflammation. Alves Cde F, Angeli GN, Favarin DC, de Andrade EL, Chica JE, Faccioli LH, da Silva PR, Rogerio Ade P. Mediators Inflamm. 2013;2013:863198. doi: 10.1155/2013/863198. Epub 2013 Nov 26. PMID: 24376308

Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model. Jean-Gilles D, Li L, Ma H, Yuan T, Chichester CO 3rd, Seeram NP. J Agric Food Chem. 2012 Jun 13;60(23):5755-62. doi: 10.1021/jf203456w. Epub 2011 Dec 1. PMID: 22111586

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Fenugreek

Fenugreek (Trigonella foenum-graecum)

Fenugreek has been found to contain protein, vitamin C, niacin, potassium, and diosgenin (which is a compound that has properties similar to estrogen). Other active constituents in fenugreek are alkaloids, lysine and L-tryptophan, as well as steroidal saponins (diosgenin, yamogenin, tigogenin, and neotigogenin).

Due to its estrogen-like properties, fenugreek has been found to help increase libido and lessen the effect of hot flashes and mood fluctuations that are common symptoms of menopause and PMS. In India and China it has also been used to treat arthritis, asthma, bronchitis, improve digestion, maintain a healthy metabolism, increase libido and male potency, cure skin problems (wounds, rashes and boils), treat sore throat, and cure acid reflux. Fenugreek also has a long history of use for the treatment of reproductive disorders, to induce labor, to treat hormonal disorders, and to reduce menstrual pain. Recent studies have shown that Fenugreek helps lower blood glucose and cholestrol levels, and may be an effective treatment for both type 1 and 2 diabetes. It is also being studied for its cardiovascular benefits.

Immunomodulatory, beta-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes. Hamden K, Masmoudi H, Carreau S, Elfeki A. Immunopharmacol Immunotoxicol. 2010 Jan 25. [Epub ahead of print] PMID: 20100065 [PubMed - as supplied by publisher]

A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Chevassus H, Gaillard JB, Farret A, Costa F, Gabillaud I, Mas E, Dupuy AM, Michel F, Cantié C, Renard E, Galtier F, Petit P. Eur J Clin Pharmacol. 2009 Dec 18. [Epub ahead of print] PMID: 20020282 [PubMed - as supplied by publisher]

Fenugreek seeds reduce atherogenic diet-induced cholesterol gallstone formation in experimental mice. Reddy RL, Srinivasan K. Can J Physiol Pharmacol. 2009 Nov;87(11):933-43. PMID: 19935901 [PubMed - in process]

Dietary fenugreek seed regresses preestablished cholesterol gallstones in mice. Reddy RL, Srinivasan K. Can J Physiol Pharmacol. 2009 Sep;87(9):684-93. PMID: 19794519 [PubMed- in process]

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GABA (gamma-aminobutyric acid)
See also chlorella

Gamma-aminobutyric acid is an neurotransmitter, and as such it serves the brain by regulating the firing of neurons.

Without GABA, your muscles would be constantly tense, your mind would never stop racing, and your overall ability to function would be severely impaired. GABA supplements can be taken to increase this valuable resource in your body.

GABA may be helpful for active individuals, bodybuilders and athletes. They may help in enhancing the body’s muscle mass, which is one of GABA’s anabolic and lipotropic properties to help in fat reduction and weight loss programs.

Inhibitory role for GABA in autoimmune inflammation including multiple sclerosis Bhat R, Axtell R, Mitra A, Miranda M, Lock C, Tsien RW, Steinman L. Proc Natl Acad Sci U S A. 2010 Feb 1. [Epub ahead of print] PMID: 20133656 [PubMed - as supplied by publisher]

Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. Shimada M, Hasegawa T, Nishimura C, Kan H, Kanno T, Nakamura T, Matsubayashi T. Clin Exp Hypertens. 2009 Jun;31(4):342-54.
PMID: 19811362 [PubMed - indexed for MEDLINE]

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Ginger Root

A perennial herb native to China and India, ginger root has been used for centuries in Asian cooking and medications. Ancient peoples used ginger root to cure everything from menstrual cramps to seasickness to food poisoning to body odor.

It is well known that ginger helps with digestive problems, hence ginger ale for a stomach ache, but there are many other health benefits as well:

  • Aids in Digestion
  • Alleviates High Blood Pressure
  • Helps with Nausea and Morning Sickness
  • Lowers LDL Cholesterol

Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. Abdulrazaq NB, Cho MM, Win NN, Zaman R, Rahman MT. Br J Nutr. 2011 Dec 12:1-8. [Epub ahead of print] PMID: 22152092 [PubMed - as supplied by publisher]

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Ginkgo Biloba

Ginkgo biloba has been used medicinally for thousands of years. Today, it's one of the top-selling herbs in the United States.

Ginkgo is used for the treatment of numerous conditions, many of which are under scientific investigation. Available evidence demonstrates ginkgo's efficacy in the management of intermittent claudication, Alzheimer's/multi-infarct dementia, and "cerebral insufficiency" (a syndrome thought to be secondary to atherosclerotic disease, characterized by impaired concentration, confusion, decreased physical performance, fatigue, headache, dizziness, depression, and anxiety).

There is promising early evidence for the use of ginkgo for memory enhancement in healthy subjects, altitude sickness, symptoms of premenstrual syndrome (PMS), age-related eye disorders, and the reduction of chemotherapy-induced end-organ vascular damage.

The results on the protective effect of ginkgo biloba extract on neuron cells. Zhao B.Mol Neurobiol. 2005;31(1-3):283-93. Review. PMID: 15953828 [PubMed - indexed for MEDLINE]

Dietary supplement with a combination of Rhodiola and Ginkgo biloba enhances the endurance performance in healthy volunteers. Zhang ZJ, Tong Y, Zou J, Chen PJ, Yu DH. Chin J Integr Med. 2009 Jun;15(3):177-83. Epub 2009 Jul 2. PMID: 19568709 [PubMed - indexed for MEDLINE]

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Ginseng Korean (Panax)

The word panax is formed from ancient Greek meaning "cure-all," and Panax ginseng has long been considered to be one of the great healing and strengthening herbs in natural medicine. Ginseng is classified as an adaptogen that helps the body adapt to stress and balance itself without side effects. Korean ginseng is used for improving overall health and stamina, and Chinese herbalists particularly recommend it for the ill, weak, or elderly.

Ginseng reputation is for longevity, anti-senility, and memory improvement effects in the elderly. Athletes use it for herbal support during rigorous training. Panax generally increases physical and mental energy. It's a good tonic for the adrenal glands, and is used by those suffering from exhaustion, burnout, or debilitation from chronic illness.

Therapeutic potential of Rhodiola and ginseng root preparations in treating diabetes mellitus Arushanian EB. Eksp Klin Farmakol. 2009 Nov-Dec;72(6):52-6. Review. Russian. PMID: 20095403 [PubMed - indexed for MEDLINE]

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Glycerine

While glycerine is metabolized on the order of a carbohydrate, it does not act physiologically in the body like a simple carbohydrate or a sugar. It does not elicit the same glycemic response, or have the same effect on insulin secretion or activity as carbohydrates.

The FDA now regards glycerine as a valuable result-producing nutrient. Counting glycerine calories as carbohydrate calories does not change the fact that glycerine is still proportionally very low in carbohydrates.

As a nutrient in skin care products, the scientific studies show its anti-wrinkle and anti-sagging benefits.

Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects. Peirano RI, Achterberg V, Düsing HJ, Akhiani M, Koop U, Jaspers S, Krüger A, Schwengler H, Hamann T, Wenck H, Stäb F, Gallinat S, Blatt T. J Cosmet Dermatol. 2011 Dec;10(4):273-81. doi: 10.1111/j.1473-2165.2011.00579.x. PMID: 22151935 [PubMed - in process]

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Goji (Lycium barbarum)

Goji, also known as Wolfberry, is well-known in traditional Chinese herbal medicine. This berry was named, in the July 24th, 2006 issue of Time Magazine, as the “Breakthrough Superfruit of the Year”. There have been several studies reported at PubMed.org that show that goji berries contains antioxidants and that goji extracts may help to prevent the growth of mutated cells and help with insulin potentiation.

Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer. Goji Luo Q, Li Z, Yan J, Zhu F, Xu RJ, Cai YZ.J Med Food. 2009 Aug;12(4):695-703.

Chemoprevention of colorectal cancer-experimental and clinical aspects. Takayama T, Goji T, Taniguchi T, Inoue A. J Med Invest. 2009 Feb;56(1-2):1-5. Review

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Green TEA (See also EGCG)

Green tea is said to provide you with excellent health benefits when consumed in moderation on a regular basis. This is due primarily to the fact that green tea is an excellent source of epigallocatechin gallate, also known as EGCG. EGCG is an antioxidant which is believed to have positive effects in protecting the human body against various types of degenerative health problems. Research has shown you can improve your overall health and ward off likelihood of health problems by incorporating it as a regular part of your daily diet.

The promise of naturally occurring phytochemicals and green tea polyphenols for blocking early events in skin carcinogenesis. Clifford JL, Digiovanni J. Cancer Prev Res (Phila Pa). 2010 Feb;3(2):132-5. Epub 2010 Jan 26. PMID: 20103730 [PubMed - in process]

Green Tea Polyphenols Prevent UV-Induced Immunosuppression Katiyar SK, Vaid M, van Steeg H, Meeran SM. Cancer Prev Res (Phila Pa). 2010 Feb;3(2):179-89. Epub 2010 Jan 26. PMID: 20103727 [PubMed - in process]

Green Tea Extract May Treat Uterine Fibroids An extract from green tea may be useful in treating uterine fibroids, WebMD Health News

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Guggul (Myrrh)

Guggul is a small, thorny plant native to India. The resin has been used in connection with a wide variety of conditions, including rheumatism and obesity. Guggul contains ketonic steroid compounds known as guggulsterones which are believe to be responsible for guggul's cholesterol- and triglyceride-lowering actions.

Scientific studies have shown guggul increase the production of the thyroid hormone. Since this hormone is involved in the cells' breakdown of protein, fat, and carbohydrates, this herb should promote weight loss.

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Hawthorn Berry (Crataegus monogyna)

Hawthorn has been used for hundreds of years to promote the health of the circulatory system, treat angina, high blood pressure, congestive heart failure and cardiac arrhythmia and has been found to strengthen the heart. Hawthorn is widely regarded in Europe as a safe and effective treatment for early stages of heart disease and has been used for a number of ailments including angina, myocarditis, arteriosclerosis, nervous conditions like insomnia, and diarrhea. It has also been indicated for strengthening blood vessels, vascular insufficiency and blood clots, restoring the heart muscle wall, lowering cholesterol and to aid digestion.

A study of the comparative effects of hawthorn fruit compound and simvastatin on lowering blood lipid levels and prevention of atherosclerosis. Xu H, Xu HE, Ryan D. Am J Chin Med. 2009;37(5):903-8. PMID: 19885950 [PubMed - indexed for MEDLINE]

Free radical-scavenging activities of Crataegus monogyna extracts. Bernatoniene J, Masteikova R, Majiene D, Savickas A, Kevelaitis E, Bernatoniene R, Dvorácková K, Civinskiene G, Lekas R, Vitkevicius K, Peciura R. Medicina (Kaunas). 2008;44(9):706-12. PMID: 18971609 [PubMed - indexed for MEDLINE]

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Japanese Knotweed (Polygonum cuspidatum) See also Resveratrol

Japanese Knotweed is a highly medicinal and edible plant that is currently being used as treatment for Lyme disease.

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Klamath Blue Green Algae

Klamath Blue Green Algae

Effect of a Klamath algae product ("AFA-B12") on blood levels of vitamin B12 and homocysteine in vegan subjects: a pilot study. Baroni L, Scoglio S, Benedetti S, Bonetto C, Pagliarani S, Benedetti Y,Rocchi M, Canestrari F. Int J Vitam Nutr Res. 2009 Mar;79(2):117-23. PMID: 20108213 [PubMed - in process]

Effect of a 2-month treatment with Klamin, a Klamath algae extract, on the general well-being, antioxidant profile and oxidative status of postmenopausal women. Scoglio S, Benedetti S, Canino C, Santagni S, Rattighieri E, Chierchia E, Canestrari F, Genazzani AD. Gynecol Endocrinol. 2009 Apr;25(4):235-40. PMID: 19408172 [PubMed - indexed for MEDLINE]

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Irish Moss (Chondrus crispus)

Irish Moss or Carrageen Moss, is a sea vegetable with about 10 percent protein and contains lots of minerals, it is especially rich in iodine and sulfur. It's also high in calcium and good for the libido.

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Lactobacillus Acidophilus

Lactobacillus acidophilus belongs to a group of bacteria that normally live in the human small intestine and vagina.
L. acidophilus is one of the most commonly used probiotics. These probiotics are microorganisms that help to maintain a healthy intestinal tract and aid digestion.

Antibacterial activity of Lactobacillus acidophilus and Lactobacillus casei against methicillin-resistant Staphylococcus aureus (MRSA). Karska-Wysocki B, Bazo M, Smoragiewicz W. Microbiol Res. 2010 Jan 27. [Epub ahead of print] PMID: 20116228 [PubMed - as supplied by publisher]

Two stomach-originated lactobacillus strains improve Helicobacter pylori infected murine gastritis. Cui Y, Wang CL, Liu XW, Wang XH, Chen LL, Zhao X, Fu N, Lu FG. World J Gastroenterol. 2010 Jan 28;16(4):445-52. PMID: 20101769 [PubMed - in process]

Expression profile analysis of intestinal Caco-2 cells treated with Lactobacillus acidophilus NCFM Wang M, Zhang G, Han X, Yao L, Zhou Y, Jiang Y. Wei Sheng Wu Xue Bao. 2009 Sep 4;49(9):1247-52. Chinese. PMID: 20030066 [PubMed - indexed for MEDLINE

Multi step mechanism of probiotic bacterium, the effect on innate immune system. (Inflammatory Bowel Disease Amit-Romach E, Uni Z, Reifen R. Mol Nutr Food Res. 2009 Dec 8;54(2):277-284. [Epub ahead of print] PMID: 19998380 [PubMed - as supplied by publisher]

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Lactobacillus Bulgaricus

Live and lyophilized Lactobacillus species elicit differential immunomodulatory effects on immune cells. Cai S, Bay BH, Lee YK, Lu J, Mahendran R. FEMS Microbiol Lett. . [Epub ahead of print] PMID: 20002187 [PubMed - as supplied by publisher]

Immunomodulation and antivirus properties of bacteria of Lactobacillus genus [No authors listed] Mikrobiol Z. 2009 May-Jun;71(3):41-7. Russian. PMID: 19938605 [PubMed - in process]

Exploring the acidotolerance of beta-galactosidase from Lactobacillus delbrueckii subsp. bulgaricus: an attractive enzyme for lactose intolerance. Rhimi M, Aghajari N, Jaouadi B, Juy M, Boudebbouze S, Maguin E, Haser R, Bejar S. Res Microbiol. 2009 Dec;160(10):775-84. Epub 2009 Sep 26. PMID: 19786095[PubMed - in process]

Hydrolytic breakdown of lactoferricin by lactic acid bacteria. Paul M, Somkuti GA. J Ind Microbiol Biotechnol. 2010 Feb;37(2):173-8. Epub 2009 Nov 19. PMID: 19924455 [PubMed - in process]

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Lavender Oil (Lavendular angustifolia)

Comparative study of the chemical composition and antioxidant activity of six essential oils and their components. Yang SA, Jeon SK, Lee EJ, Shim CH, Lee IS. Nat Prod Res. 2010;24(2):140-51. PMID: 20077307 [PubMed - in process]

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Licorice Root Extract (Glycyrrhiza glabra)

Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma. Houssen ME, Ragab A, Mesbah A, El-Samanoudy AZ, Othman G, Fathy A, Badria FA. Clin Biochem. 2010 Apr 26. [Epub ahead of print] PMID: 20430018 [PubMed - as supplied by publisher]

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Mangosteen (Garcinia Mangostana)

Mangosteen contains antioxidants called Xanthones, some of the most powerful antioxidants ever discovered. Xanthones themselves have been studied in over 220 clinical trials. According to published studies Mangosteen is considered to be a natural Cox-2 inhibitor and a powerful natural anti-inflammatory that may be more powerful and potent than aspirin with no side effects!

Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer. Doi H, Shibata MA, Shibata E, Morimoto J, Akao Y, Iinuma M, Tanigawa N, Otsuki Y. Anticancer Res. 2009 Jul;29(7):2485-95.

Potential of Xanthones from Tropical Fruit Mangosteen as Anti-cancer Agents. Watanapokasin R, Jarinthanan F, Jerusalmi A, Suksamrarn S, Nakamura Y, Sukseree S, Uthaisang-Tanethpongtamb W, Ratananukul P, Sano T. Appl Biochem Biotechnol. 2010 Jan 26. [Epub ahead of print] PMID: 20101528 [PubMed - as supplied by publisher]

Comparison of bioactive compounds content, free radical scavenging and anti-acne inducing bacteria activities of extracts from the mangosteen fruit rind at two stages of maturity. Pothitirat W, Chomnawang MT, Supabphol R, Gritsanapan W. Fitoterapia. 2009 Oct;80(7):442-7. Epub 2009 Jun 12.

Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. Bumrungpert A, Kalpravidh RW, Chitchumroonchokchai C, Chuang CC, West T, Kennedy A, McIntosh M J Nutr. 2009 Jun;139(6):1185-91.Epub 2009 Apr 29

Anti-cancer effects of xanthones from pericarps of mangosteen. Akao Y, Nakagawa Y, Iinuma M, Nozawa Y. Int J Mol Sci. 2008 Mar;9(3):355-70. Epub 2008 Mar 14.

The natural xanthone alpha-mangostin reduces oxidative damage in laboratory animal brain tissue. Márquez-Valadez B, Lugo-Huitrón R, Valdivia-Cerda V, Miranda-Ramírez LR, Pérez-De La Cruz V, González-Cuahutencos O, Rivero-Cruz, Mata R, Santamaría A, Pedraza-Chaverrí J. Nutr Neurosci. 2009 Feb;12(1):35-42.

Garcinia mangostana L.: a phytochemical and pharmacological review. Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Phytother Res. 2009 Aug;23(8):1047-65.

Medicinal properties of mangosteen (Garcinia mangostana). Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M, Pérez-Rojas JM. Food Chem Toxicol. 2008 Oct;46(10):3227-39. Epub 2008 Aug 6. Review.

Anti-inflammatory activity of mangostins from Garcinia mangostana. Chen LG, Yang LL, Wang CC. Food Chem Toxicol. 2008 Feb;46(2):688-93. Epub 2007 Sep 26.

Oligomeric proanthocyanidins from mangosteen pericarps much higher than that of pine bark and grape seed extracts. Fu C, Loo AE, Chia FP, Huang D. J Agric Food Chem. 2007 Sep 19;55(19):7689-94. Epub 2007 Aug 23.

Antimicrobial activity in cultures of endophytic fungi isolated from Garcinia species. Phonographic S, Rungjindamai N, Rukachaisirikul V, Sakayaroj J. FEMS Immunol Med Microbiol. 2006 Dec;48(3):367-72. Epub 2006 Oct 18.

Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Matsumoto K, Akao Y, Yi H, Ohguchi K, Ito T, Tanaka T, Kobayashi E, Iinuma M, Nozawa Y. Bioorg Med Chem. 2004 Nov 15;12(22):5799-806.

Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. Gopalakrishnan G, Banumathi B, Suresh G. J Nat Prod. 1997 May;60(5):519-24.

Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.Chairungsrilerd N, Furukawa K, Ohta T, Nozoe S, Ohizumi Y. Planta Med. 1996 Oct;62(5):471-2.

Active constituents against HIV-1 protease from Garcinia mangostana. Chen SX, Wan M, Loh BN. Planta Med. 1996 Aug;62(4):381-2.

Antimicrobial activities of Garcinia mangostana. Sundaram BM, Gopalakrishnan C, Subramanian S, hankaranarayanan D, Kameswaran L. Planta Med. 1983 May;48(1):59-60.

Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells. Romier-Crouzet B, Van De Walle J, During A, Joly A, Rousseau C, Henry O, Larondelle Y, Schneider YJ. Food Chem Toxicol. 2009 Jun;47(6):1221-30. Epub 2009 Feb 20.

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Maqui (Aristotelia chilensis)

The Maqui berry, considered a very powerful anti-oxidant, may have the highest antioxidant value of any known fruit and contains high levels of polyphenols and anthocyanins which may protect cells from oxidative stress. Other benefits may include: neutralizing free radicals, supporting healthy circulation and lowering inflammation.

Anthocyanins in berries of Maqui (Aristotelia chilensis (Mol.) Stuntz). Escribano-Bailón MT, Alcalde-Eon C, Muñoz O, Rivas-Gonzalo JC, Santos-Buelga C. Phytochem Anal. 2006 Jan-Feb;17(1):8-14

Antioxidant capacity of fruits and vegetables cultivated in Chile Araya H, Clavijo C, Herrera C. Arch Latinoam Nutr. 2006 Dec;56(4):361-5. Spanish

Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance and disease. Seeram NP. J Agric Food Chem. 2008 Feb 13;56(3):627-9. Epub 2008 Jan 23

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Muscadine Grape (Vitis rotundifolia)

Muscadine Grapes have an extra chromsome (compared to other grapes) and this is the reason they have incredible health properties. While Resveratrol is found in all red grapes, the Muscadine grape has over 6 times the amount of Resveratrol found in red grapes. Research has shown that resveratrol may help prevent heart disease by increasing levels of "good" cholesterol and protecting against artery damage.

Heterogeneity in muscadine grape polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration. Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow D, Humala N, Cheng A, Percival SS, Ferruzzi M, Janle E, Dickstein DL, Pasinetti GM. J Alzheimers Dis. 2009 Jan;16(1):59-72. PMID: 19158422 [PubMed - indexed for MEDLINE]

Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE. Cancer Res. 2007 Sep 1;67(17):8396-405. PMID: 17804756 [PubMed - indexed for MEDLINE]

Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Banini AE, Boyd LC, Allen JC, Allen HG, Sauls DL. Nutrition. 2006 Nov-Dec;22(11-12):1137-45. Epub 2006 Oct 9. PMID: 17030113 [PubMed - indexed for MEDLINE]

Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitis rotundifolia). Mertens-Talcott SU, Lee JH, Percival SS, Talcott ST. J Agric Food Chem. 2006 Jul 26;54(15):5336-43. PMID: 16848514 [PubMed - indexed for MEDLINE]

Anti-inflammatory properties of the muscadine grape (Vitis rotundifolia). Greenspan P, Bauer JD, Pollock SH, Gangemi JD, Mayer EP, Ghaffar A, Hargrove JL, Hartle DK. J Agric Food Chem. 2005 Nov 2;53(22):8481-4. PMID: 16248541 [PubMed - indexed for MEDLINE]

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Opti-Zinc (See also Zinc)

Zinc, like iron, copper and chromium, is one of 16 essential trace minerals the body needs to keep healthy and fit. And for people that are sick or out of shape, zinc may be the most precious metal of all. Zinc is essential for growth and development, reproduction, digestion, respiration, and for proper brain, nerve, vision and immune function. OptiZinc® is a unique, patented form of methionine-bound zinc that dramatically increase the bioavailability of zinc. Researchers have shown that OptiZinc is by far the most potent zinc antioxidant available as a dietary supplement.

Long-Term Intake of OptiZinc® and ChromeMate® Reduce Oxidation, Lower Blood Pressure and Improve Blood Sugar Status Source: Preuss HG, Montamarry S, Echard B, Scheckenbach R, Bagchi D, Long-Term Effects of Chromium, Grape Seed Extract, and Zinc on Various Metabolic Parameters of Rats Molecular and Cellular Biochemistry, 223:95-102, 2001

ChromeMate® and OptiZinc® Found to Reduce Signs of Aging Source: Preuss HG, Montamarry S, Echard B, Scheckenbach R, Bagchi D, Long-Term Effects of Chromium, Grape Seed Extract and Zinc on Various Metabolic Parameters of Rats, Molecular and Cellular Biochemistry, 223:95-102, 2001

L-OptiZinc® and OptiZinc® Significantly Reduce Oxidative Damage Source: Bagchi D, Vuchetich PJ, Bagchi M, Tran MX, Krohn RL, Ray SD, Stohs SJ, Protective Effects of Zinc Salts on TPA-Induced Hepatic and Brain Lipid Peroxidation, Glutathione Depletion, DNA Damage and Peritoneal Macrophage Activation in Mice, General Pharmacology, 30:43-50, 1998.

OptiZinc® Effective In Reducing Oxidation Source: Bagchi D, Bagchi M, Stohs SJ, Comparative In Vitro Oxygen Radical Scavenging Ability of Zinc Methionine and Selected Zinc Salts and Antioxidants, General Pharmacology, 28:85-91, 1997.

Zinc: An Essential Micronutrient Source: Bagchi D, Stohs SJ, Bagchi M. Zinc: An Essential Micronutrient and Chemoprotectant, Nutritional Perspectives: Journal of the Council on Nutrition of the American Chiropractic Association, 19:13-19, 1996.

OptiZinc® Found More Bioavailable than Other Zinc Supplements Source: Wedekind KJ, Hortin AE, Baker DH, Methodology for Assessing Zinc Bioavailability: Efficacy Estimates for Zinc-Methionine, Zinc Sulfate, and Zinc Oxide, Journal of Animal Science, 70:178-187, 1992

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Papaya (Carica papaya L. Caricaceae)

Papaya enzyme is called papain, a digestive enzyme that helps break down certain types of food in the stomach. Papain is especially useful in breaking down protein. Consequently, it's often used in cooking and baking as a meat tenderizer. Papain also has a soothing effect on the stomach. Red meat, fish and certain types of vegetables high in protein can be broken down and absorbed by the stomach readily with the help of digestive enzymes.

According to WHFoods.com, papaya enzyme also has an anti-inflammatory effect in the body, helping speed up the healing process after a burn or injury.

Papaya enzyme also has several health benefits. According to WHFoods.com, papain can be used to treat certain types of sports injuries, allergy attacks and may also improve digestive health. According to some studies, papain, the enzyme found in papaya, contains properties that can break down venom and other proteins, thereby protecting our immune systems.

Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. Otsuki N, Dang NH, Kumagai E, Kondo A, Iwata S, Morimoto C. J Ethnopharmacol. 2009 Dec 2. [Epub ahead of print] PMID: 19961915 [PubMed - as supplied by publisher]

Carica papaya (Paw-Paw) unripe fruit may be beneficial in ulcer. Ezike AC, Akah PA, Okoli CO, Ezeuchenne NA, Ezeugwu S. J Med Food. 2009 Dec;12(6):1268-73. doi: 10.1089/jmf.2008.0197. PMID: 20041780 [PubMed - indexed for MEDLINE]

Thrombocyte counts in mice after the administration of papaya leaf suspension. Sathasivam K, Ramanathan S, Mansor SM, Haris MR, Wernsdorfer WH. Wien Klin Wochenschr. 2009 Oct;121 Suppl 3:19-22. PMID: 19915811 [PubMed - in process]

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PEA

Phenylethylamine (PEA)

Phenethylamine is the ingredient in chocolate which is thought to provide the mood-elevating effects. PEA stimulates the nervous system and triggers the release of pleasurable compounds known as endorphins which supress pain and are the origin of runners high. Dietary PEA can give you the euphoric feeling of exercise without the exercise. It also potentiates the activity of dopamine, a neurochemical directly associated with sexual arousal and pleasure.

Sustained antidepressant effect of PEA replacement by Sabelli H; Fink P; Fawcett J; Tom C Rush University and the Center for Creative Development, Chicago, Illinois, USA. Phenylethylamine, a possible link to the antidepressant effects of exercise A Szabo, E Billett, and J Turner Br. J. Sports Med., October 1, 2001; 35(5): 342 - 343.

Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine. Kitaichi Y, Inoue T, Nakagawa S, Boku S, Izumi T, Koyama T. Eur J Pharmacol. 2010 Apr 18. [Epub ahead of print]
PMID: 20406628 [PubMed - as supplied by publisher]

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Pomegranate (Punica granatum L. Punicaceae)

Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins. Kasimsetty SG, Bialonska D, Reddy MK, Ma G, Khan SI, Ferreira D. J Agric Food Chem. 2010 Jan 29. [Epub ahead of print] PMID: 20112993 [PubMed - as supplied by publisher]

Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation. Bae JY, Choi JS, Kang SW, Lee YJ, Park J, Kang YH. Exp Dermatol. 2010 Jan 25. [Epub ahead of print] PMID: 20113347 [PubMed - as supplied by publisher]

Nutraceuticals and prostate cancer prevention: a current review. Trottier G, Boström PJ, Lawrentschuk N, Fleshner NE. Nat Rev Urol. 2010 Jan;7(1):21-30. Epub 2009 Dec 8. PMID: 19997071 [PubMed - in process]

Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. Kasimsetty SG, Bialonska D, Reddy MK, Thornton C, Willett KL, Ferreira D. J Agric Food Chem. 2009 Nov 25;57(22):10636-44. PMID: 19919114 [PubMed - in process]

Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Koyama S, Cobb LJ, Mehta HH, Seeram NP, Heber D, Pantuck AJ, Cohen P. Growth Horm IGF Res. 2010 Feb;20(1):55-62. Epub 2009 Oct 22. PMID: 19853487 [PubMed - in process]

Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferation. Grossmann ME, Mizuno NK, Schuster T, Cleary MP. Int J Oncol. 2010 Feb;36(2):421-6. PMID: 20043077 [PubMed - in process]

Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Cancer Prev Res (Phila Pa). 2010 Jan;3(1):108-13. PMID: 20051378 [PubMed - in process]

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Blueberries

Pterostilbene (Blueberry)

Pterostilbene and cancer: current review.McCormack D, McFadden D. J Surg Res. 2012 Apr;173(2):e53-61. doi: 10.1016/j.jss.2011.09.054. Epub 2011 Oct 21. Review. PMID: 22099605 [PubMed - indexed for MEDLINE

Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells. Paul S, Rimand AM, Lee HJ, Ji Y, Reddy BS, Suh N. Source: Dept. of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats. Paul S, DeCastro AJ, Lee HJ, Smolarek AK, So JY, Simi B, Wang CX, Zhou R, Rimando AM, Suh N. Source: Dept. of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Pterostilbene ameliorates tumor necrosis factor alpha-induced pancreatitis in vitro.
McCormack D, McDonald D, McFadden D. J Surg Res. 2012 Nov;178(1):28-32. doi: 10.1016/j.jss.2012.08.004. Epub 2012 Aug 23. PMID 22954523 [PubMed - in process]

Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells.Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD. J Agric Food Chem. 2012 Jun 27;60(25):6399-407. doi: 10.1021/jf301499e. Epub 2012 Jun 19. PMID: 22670709 [PubMed - indexed for MEDLINE]

Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro.Kostin SF, McDonald DE, McFadden DW.J Surg Res. 2012 Oct;177(2):255-62. doi: 10.1016/j.jss.2012.04.023. Epub 2012 May 3

Pterostilbene induces mitochondrially derived apoptosis in breast cancer cells in vitro. Moon D, McCormack D, McDonald D, McFadden D. J Surg Res. 2012 Apr 29. [Epub ahead of print] PMID: 22572619 [PubMed - as supplied by publisher]

Pterostilbene simultaneously induces apoptosis, cell cycle arrest and cyto-protective autophagy in breast cancer cells. Wang Y, Ding L, Wang X, Zhang J, Han W, Feng L, Sun J, Jin H, Wang XJ. Am J Transl Res. 2012;4(1):44-51. Epub 2012 Jan 5. PMID: 22347521[PubMed]

Low-dose pterostilbene is a potent neuromodulator in aging and Alzheimer's disease. Chang J, Rimando A, Pallas M, Camins A, Porquet D, Reeves J, Shukitt-Hale B, Smith MA, Joseph JA, Casadesus G. Neurobiol Aging. 2012 Sep;33(9):2062-71. doi: 10.1016/j.neurobiolaging.2011.08.015. Epub 2011 Oct 7. PMID: 21982274 [PubMed - indexed for MEDLINE]

Pterostilbene suppresses benzo[a]pyrene-induced airway remodeling, helps with asthsma. Kuo PL, Hsu YL, Tsai MJ, Huang MS. J Agric Food Chem. 2011 Jul 27;59(14):8028-35. doi: 10.1021/jf201747g. Epub 2011 Jun 21. PMID: 21675704 [PubMed - indexed for MEDLINE

Utilization of pterostilbene for evaluation of new approaches in rheumatoid arthritis therapy focused on regulation of immune processes and oxidative stress. Bauerová K, Poništ S, Mihalová D, Dráfi F, Kuncírová V. Interdiscip Toxicol. 2011 Mar;4(1):33-9. doi: 10.2478/v10102-011-0007-9. PMID: 21577282 [PubMed]

Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. Chiou YS, Tsai ML, Nagabhushanam K, Wang YJ, Wu CH, Ho CT, Pan MH. J Agric Food Chem. 2011 Mar 23;59(6):2725-33. doi: 10.1021/jf2000103. Epub 2011 Feb 28. PMID: 21355597 [PubMed - indexed for MEDLINE]

Chemical principles and bioactivities of blueberry. Chen CF, Li YD, Xu Z. Yao Xue Xue Bao. 2010 Apr;45(4):422-9. Review. Chinese. PMID: 21355205 [PubMed - indexed for MEDLINE]

Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. Nutakul W, Sobers HS, Qiu P, Dong P, Decker EA, McClements DJ, Xiao H. J Agric Food Chem. 2011 Oct 26;59(20):10964-70. doi: 10.1021/jf202846b. Epub 2011 Sep 29. PMID: 21936500 [PubMed - indexed for MEDLINE

Pterostilbene and tamoxifen show an additive effect against breast cancer in vitro.Mannal P, McDonald D, McFadden D. Am J Surg. 2010 Nov;200(5):577-80. doi: 10.1016/j.amjsurg.2010.07.022. PMID: 21056131 [PubMed - indexed for MEDLINE]

Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells. Chen RJ, Ho CT, Wang YJ. Mol Nutr Food Res. 2010 Dec;54(12):1819-32. doi: 10.1002/mnfr.201000067. PMID: 20603834 [PubMed - indexed for MEDLINE]

Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway.Park ES, Lim Y, Hong JT, Yoo HS, Lee CK, Pyo MY, Yun YP. Vascul Pharmacol. 2010 Jul-Aug;53(1-2):61-7. doi: 10.1016/j.vph.2010.04.001. Epub 2010 Apr 14. PMID: 20398797 [PubMed - indexed for MEDLINE]

Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG2 hepatoma and Chang liver cells: Implications for structure activity relationship. Hasiah AH, Ghazali AR, Weber JF, Velu S, Thomas NF, Inayat Hussain SH. Hum Exp Toxicol. 2011 Feb;30(2):138-44. doi: 10.1177/0960327110368739. Epub 2010 Apr 12. PMID: 20385705 [PubMed - indexed for MEDLINE]

Pterostilbene inhibits pancreatic cancer in vitro. Mannal PW, Alosi JA, Schneider JG, McDonald DE, McFadden DW. J Gastrointest Surg. 2010 May;14(5):873-9. doi: 10.1007/s11605-010-1164-4. Epub 2010 Feb 6. PMID: 20140535 [PubMed - indexed for MEDLINE]

Pterostilbene inhibits breast cancer in vitro through mitochondrial depolarization and induction of caspase-dependent apoptosis. Alosi JA, McDonald DE, Schneider JS, Privette AR, McFadden DW. J Surg Res. 2010 Jun 15;161(2):195-201. doi: 10.1016/j.jss.2009.07.027. Epub 2009 Aug 18. PMID: 20031172 [PubMed - indexed for MEDLINE]

Pterostilbene inhibits lung cancer through induction of apoptosis. Schneider JG, Alosi JA, McDonald DE, McFadden DW. J Surg Res. 2010 Jun 1;161(1):18-22. doi: 10.1016/j.jss.2009.06.027. Epub 2009 Jul 21. PMID: 20031166 [PubMed - indexed for MEDLINE]

Effects of pterostilbene on melanoma alone and in synergy with inositol hexaphosphate. Schneider JG, Alosi JA, McDonald DE, McFadden DW. Am J Surg. 2009 Nov;198(5):679-84. doi: 10.1016/j.amjsurg.2009.07.014. PMID: 19887199 [PubMed - indexed for MEDLINE]

Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation. Pan MH, Lin YT, Lin CL, Wei CS, Ho CT, Chen WJ. Evid Based Complement Alternat Med. 2011;2011:562187. doi: 10.1093/ecam/nep093. Epub 2011 Feb 14. PMID: 19617202 [PubMed]

Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells. Paul S, Rimando AM, Lee HJ, Ji Y, Reddy BS, Suh N. Cancer Prev Res (Phila). 2009 Jul;2(7):650-7. doi: 10.1158/1940-6207.CAPR-08-0224. Epub 2009 Jun 23. PMID: 19549798 [PubMed - indexed for MEDLINE]

Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. Pan MH, Chiou YS, Chen WJ, Wang JM, Badmaev V, Ho CT. Carcinogenesis. 2009 Jul;30(7):1234-42. doi: 10.1093/carcin/bgp121. Epub 2009 May 15. PMID: 19447859 [PubMed - indexed for MEDLINE]

Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic. Ruiz MJ, Fernández M, Picó Y, Mañes J, Asensi M, Carda C, Asensio G, Estrela JM. J Agric Food Chem. 2009 Apr 22;57(8):3180-6. doi: 10.1021/jf803579e. PMID: 19292443 [PubMed - indexed for MEDLINE]

Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. Joseph JA, Fisher DR, Cheng V, Rimando AM, Shukitt-Hale B. J Agric Food Chem. 2008 Nov 26;56(22):10544-51. doi: 10.1021/jf802279h. PMID: 18954071 [PubMed - indexed for MEDLINE]

Biological/chemopreventive activity of stilbenes and their effect on colon cancerRimando AM, Suh N. Planta Med. 2008 Oct;74(13):1635-43. doi: 10.1055/s-0028-1088301. Epub 2008 Oct 8. Review. PMID: 18843589 [PubMed - indexed for MEDLINE]

Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. Pan MH, Chang YH, Tsai ML, Lai CS, Ho SY, Badmaev V, Ho CT. J Agric Food Chem. 2008 Aug 27;56(16):7502-9. doi: 10.1021/jf800820y. Epub 2008 Jul 26. PMID: 18656926 [PubMed - indexed for MEDLINE]

Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity. Remsberg CM, Yáñez JA, Ohgami Y, Vega-Villa KR, Rimando AM, Davies NM. Phytother Res. 2008 Feb;22(2):169-79. PMID: 17726731 [PubMed - indexed for MEDLINE]

Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells. Pan MH, Chang YH, Badmaev V, Nagabhushanam K, Ho CT. J Agric Food Chem. 2007 Sep 19;55(19):7777-85. Epub 2007 Aug 16. PMID: 17696482 [PubMed - indexed for MEDLINE]

The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats. Amarnath Satheesh M, Pari L. J Pharm Pharmacol. 2006 Nov;58(11):1483-90. PMID: 17132211 [PubMed - indexed for MEDLINE]

Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Suh N, Paul S, Hao X, Simi B, Xiao H, Rimando AM, Reddy BS. Clin Cancer Res. 2007 Jan 1;13(1):350-5. PMID: 17200374 [PubMed - indexed for MEDLINE]

Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats.Pari L, Satheesh MA. Life Sci. 2006 Jul 10;79(7):641-5. Epub 2006 Apr 17. PMID: 16616938 [PubMed - indexed for MEDLINE]

Pterostilbene is an effective apoptosis-inducing agent in MDR and BCR-ABL-expressing leukemia cells. Tolomeo M, Grimaudo S, Di Cristina A, Roberti M, Pizzirani D, Meli M, Dusonchet L, Gebbia N, Abbadessa V, Crosta L, Barucchello R, Grisolia G, Invidiata F, Simoni D. Int J Biochem Cell Biol. 2005 Aug;37(8):1709-26. Epub 2005 Apr 26. PMID: 15878840 [PubMed - indexed for MEDLINE]

Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. Rimando AM, Nagmani R, Feller DR, Yokoyama W. J Agric Food Chem. 2005 May 4;53(9):3403-7. PMID: 15853379 [PubMed - indexed for MEDLINE]

Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. Rimando AM, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO. span title="Journal of agricultural and food chemistry">J Agric Food Chem. 2002 Jun 5;50(12):3453-7. PMID: 12033810 [PubMed - indexed for MEDLINE]

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Resveratrol (See also Japanese Knotweed)

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases Albert Y. Sun, Qun Wang, Agnes Simonyi, Grace Y. Sun Mol Neurobiol. Author manuscript; available in PMC 2011 April 13. Published in final edited form as: Mol Neurobiol. 2010 June; 41(2-3): 375–383. Published online 2010 March 21. doi: 10.1007/s12035-010-8111-y PMCID: PMC3076208

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Rhodiola for Endurance

 Rhodiola (Rhodiola algida)

Dietary supplement with a combination of Rhodiola and Ginkgo biloba enhances the endurance performance in Zhang ZJ, Tong Y, Zou J, Chen PJ, Yu DH. Chin J Integr Med. 2009 Jun;15(3):177-83. Epub 2009 Jul 2. PMID: 19568709 [PubMed - indexed for MEDLINE]

Strong scientific evidence is available for Rhodiola rosea extract, which improved attention, cognitive function and mental performance in fatigue and in chronic fatigue syndrome Panossian A, Wikman G. Curr Clin Pharmacol. 2009 Sep;4(3):198-219. Epub 2009 Sep 1. Review. PMID: 19500070 [PubMed - indexed for MEDLINE]

Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients. Loo WT, Jin LJ, Chow LW, Cheung MN, Wang M. Expert Opin Investig Drugs. 2010 Apr;19 Suppl 1:S91-100. PMID: 20374035 [PubMed - in process]

A preliminary study: the anti-proliferation effect X, Lin S, Yu D, Qiu S, Zhang X, Mei R. Cell Biol Toxicol. 2010 Mar 23. [Epub ahead of print] PMID: 20309622 [PubMed - as supplied by publisher]

Therapeutic potential of Rhodiola and ginseng root preparations in treating diabetes mellitus Arushanian EB. Eksp Klin Farmakol. 2009 Nov-Dec;72(6):52-6. Review. Russian. PMID: 20095403 [PubMed - indexed for MEDLINE]

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Seville Orange

Seville orange is a small citrus fruit known for its sour taste. In some parts of the world, seville orange is consumed as a food, although it is usually too bitter for most people. But it's gaining notarity as a supplement in capsule form for its variety of different benefits, such as:

  • To help with weight loss by increasing metabolism;
  • To relieve heartburn and indigestion;
  • To relieve nasal congestion;
  • To support healthy blood sugar and cholesterol levels already within normal range;
  • To help with chronic fatigue.
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Say No to Soft Drinks

Soft Drinks

Soft Drink and Juice Consumption and Risk of Pancreatic Cancer: The Singapore Chinese Health Study Noel T. Mueller, Andrew Odegaard, Kristin Anderson, Jian-Min Yuan, Myron Gross, Woon-Puay Koh and Mark A. Pereira[PubMed - in process]

 

 

 

 

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Klamath Blue Green Algae

Spirulina

Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease. McCarty MF. Med Hypotheses. 2010 Jan 18. [Epub ahead of print] PMID: 20089363 [PubMed - as supplied by publisher]

The prevalence, structure and clinical problems of multiple sclerosis (MS). It has been established that intake of spirulina makes for lengthening of remission in those patients with disseminated sclerosis. [Article in Ukrainian] Buletsa BA, Ihnatovych II, Lupych PP, Pulyk OR. PMID: 9138801 [PubMed - indexed for MEDLINE]

Spirulina Promotes Stem Cell Genesis and Protects against LPS Induced Declines in Neural Stem Cell Inflammation PLoS One. 2010; 5(5): e10496. Published online 2010 May 5. doi:  10.1371/ journal.pone.0010496 Adam D. Bachstetter, Jennifer Jernberg, Andrea Schlunk,Jennifer L. Vila, Charles Hudson, Michael J. Cole, R. Douglas Shytle, Jun Tan, Paul R. Sanberg, Cyndy D. Sanberg, Cesario Borlongan, Yuji Kaneko, Naoki Tajiri, Carmelina Gemma, and Paula C. Bickford Tsuneya Ikezu, Editor

Induction of G1 cell cycle arrest and mitochondria-mediated apoptosis in MCF-7 human breast carcinoma cells by selenium-enriched Spirulina extract. Chen T, Wong YS, Zheng W. Biomed Pharmacother. 2009 Oct 27. [Epub ahead of print] PMID: 19926246 [PubMed - as supplied by publisher]

Inhibitory effects of polysaccharide extract from Spirulina platensis on corneal neovascularization. Yang L, Wang Y, Zhou Q, Chen P, Wang Y, Wang Y, Liu T, Xie L. Mol Vis. 2009 Sep 24;15:1951-61. PMID: 19784394 [PubMed - indexed for MEDLINE]

Alterations in beta-islets of Langerhans in alloxan-induced diabetic laboratory animals by marine Spirulina platensis. Muthuraman P, Senthilkumar R, Srikumar K. J Enzyme Inhib Med Chem. 2009 Apr 28. [Epub ahead of print] PMID: 19555165 [PubMed - as supplied by publisher]

Chemoprevention of liver toxicity and carcinogenesis by Spirulina. Ismail MF, Ali DA, Fernando A, Abdraboh ME, Gaur RL, Ibrahim WM, Raj MH, Ouhtit A. Int J Biol Sci. 2009 Jun 2;5(4):377-87. PMID: 19521547 [PubMed - indexed forMEDLINE

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Streptococcus thermophilus

Multistep mechanism of probiotic bacterium, the effect on innate immune system. (Inflammatory Bowel Disease Amit-Romach E, Uni Z, Reifen R. Mol Nutr Food Res. 2009 Dec 8;54(2):277-284. [Epub ahead of print] PMID: 19998380 [PubMed - as supplied by publisher]

Hydrolytic breakdown of lactoferricin by lactic acid bacteria. Paul M, Somkuti GA. J Ind Microbiol Biotechnol. 2010 Feb;37(2):173-8. Epub 2009 Nov 19. PMID: 19924455 [PubMed - in process]

Emergence of a cell wall protease in the Streptococcus thermophilus population. Delorme C, Bartholini C, Bolotine A, Ehrlich SD, Renault P. Appl Environ Microbiol. 2010 Jan;76(2):451-60. Epub 2009 Nov 13. PMID: 19915034[PubMed - in process]

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Taurine

Taurine

Taurine is one of the most plentiful amino acids in the human brain. A team of researchers at Weill Cornell Medical College (WCMC) has found that taurine is a strong activator of what are known as GABA [gamma-aminobutyric acid] receptors in a regulatory area of the brain called the thalamus. It is often formulated in energy drinks because it greatly boosts energy.

Taurine improves learning and retention in aged mice. El Idrissi A. Neurosci Lett. 2008 May 2;436(1):19-22. Epub 2008 Mar 7. PMID: 18375059 [PubMed - indexed for MEDLINE]

Taurine deficiency in thalassemia major-induced osteoporosis treated with neridronate. D'Eufemia P, Finocchiaro R, Celli M, Raccio I, Zambrano A, Tetti M, Smacchia P, Iacobini M. Biomed Pharmacother. 2010 Apr;64(4):271-4. Epub 2009 Oct 23. PMID: 20359847 [PubMed - in process]

Oxidative stress and dysregulation of the taurine transporter in high-glucose-exposed human Schwann cells: implications for pathogenesis of diabetic neuropathy. Askwith T, Zeng W, Eggo MC, Stevens MJ. Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E620-8. Epub 2009 Jul 14. PMID: 19602579 [PubMed - indexed for MEDLINE]

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Uva Ursi

Uva Ursi

The leaves of this small shrub have been used as an herbal folk medicine for centuries as a mild diuretic and astringent, and in the treatment of urinary tract infections such as cystitis, urethritis and nephritis, pyelitis and in pyelonephritis. Uva-ursi can help to reduce accumulations of uric acid and relieve the pain of bladder stones. Uva Ursi is also helpful for chronic diarrhea. As a nutritional supplement and muscle relaxant, Uva Ursi soothes, strengthens, and tightens irritated and inflamed tissues.

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Xanthones (See Mangosteen)

Yerba Maté (Ilex paraguayensis St-Hil)

Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of Yerba Maté Ranilla LG, Kwon YI, Apostolidis E, Shetty K. Bioresour Technol. 2010 Jun;101(12):4676-89. Epub 2010 Feb 25. PMID: 20185303 [PubMed - in process]

 

 

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Zinc

Zinc (See also Opti-Zinc)

Zinc, like iron, copper and chromium, is one of 16 essential trace minerals the body needs to keep healthy and fit. And for people that are sick or out of shape, zinc may be the most precious metal of all. Zinc is essential for growth and development, reproduction, digestion, respiration, and for proper brain, nerve, vision and immune function.

How does zinc supplementation benefit anorexia nervosa? Birmingham CL, Gritzner S. Eat Weight Disord. 2006 Dec;11(4):e109-11. PMID: 17272939 [PubMed - indexed for MEDLINE]

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These statements have not been evaluated by the FDA. In compliance with FDA standards LifesMiracle supplements, and/or water and air products are not intended to diagnose, treat, prevent, or cure any specific disease or its symptoms. To learn what our lawmakers have posted on the United States Senate web site with reference to nutrition and its role in the body, please refer to the following Senate Document found on www.senate.gov